Background. The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance\nan unavoidable one. This is as a result of drug misuse by health personnel and patients� noncompliance to treatment regimen.\nMonitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer\ndisease. This study therefore investigated the inhibitory activity of some antibiotics against isolates of Mycobacterium ulcerans.\nMethods. Activity of eight antibiotics was tested against twelve M. ulcerans isolates (2 reference strains and 10 clinical isolates).\nThe anti-M. ulcerans activities were determined by the agar dilution method and the minimum inhibitory concentrations (MICs)\nwere determined by the agar proportion method. Results. All antimicrobials investigated had activity against M. ulcerans isolates\ntested. The MICs ranged from 0.16
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